Whether tourism culture and economy develop in a coordinated manner is the key to realize the transformation and interaction of industrial structure. This paper takes the related data of 11 prefecture-level cities in Shanxi Province from 2013 to 2022 as the research object, and after demonstrating the intrinsic mechanism (the relationship of mutual influence) of the development of tourism culture and local economy, it applies the econometric panel Granger causality test to quantitatively test the interactive relationship between the development of tourism culture and local economy. After that, we constructed the index system of tourism culture and local economy, used entropy value method and coupling coordination model to analyze the comprehensive development level and coupling coordination degree of tourism culture system and regional economic system, and used Robust regression analysis to study the influencing factors of coupling coordination degree. The results of the study show that at the 5% significance level, with a lag of 5 and 6 periods, the local economic development is the Granger cause of tourism culture, and the local economic development has an obvious driving effect on tourism culture. In the 10 years of the examination period, the coupling coordination between tourism culture and local economy keeps growing, and the coupling coordination is improved, but there is still a certain gap with the high-quality coordination, meanwhile, the regression results show that focusing on the holistic and balanced development of the influencing factors is conducive to further coordination and interaction between the two systems.