Aiming at the shortcomings of traditional relay protection, an adaptive multi-area protection coordination model is studied and designed. Firstly, combining different control strategies such as master-slave control and sag control, a method of AC/DC distribution network trend calculation and network loss analysis based on the alternating iteration method is proposed and realized to ensure that the adaptive relay protection can act correctly. The proposed method is analyzed for AC/DC hybrid distribution network trend calculation, and the alternating iteration solution method is used for trend analysis and calculation, and the effectiveness of the proposed method is veriϐied by two examples of AC/DC hybrid distribution networks. Then the adaptive Agent with reinforcement learning is introduced, and its constructed multi-agent system has more system adaptive capability. The adaptive current interruption protection is compared with the traditional current interruption protection, and its protection principle and protection scope are analyzed, on the basis of which an adaptive coordinated protection method based on MAS grid is proposed to realize the MAS adaptive current interruption protection, and its simulation is veriϐied. The experimental results show that the method of this paper can signiϐicantly improve the ϐlexibility, effectiveness and stability of AC and DC distribution network operation.