Based on the background of information technology, this paper proposes a multimodal blended learning model of English listening based on “WeChat+Classroom+TED-Ed”. It focuses on the experimental teaching of multimodal learning and English listening comprehension, and describes the object of the study, the design of the study and the process of the study. Based on the research idea, the experimental variables were designed, and the empirical analysis was carried out by using multiple linear regression model. The teaching effect of multimodal teaching is examined by comparing the differences in the total English listening scores of the two groups of students before and after the experiment. With the help of Pearson correlation analysis, the correlation between the experimental variables is explored. The value of R² was determined through the multiple regression model to determine the magnitude of the explanatory power of multimodal learning on English listening comprehension ability. The results showed that the scores of the control class improved by 1.19 points and the experimental class improved by 4.19 points in the experimental posttest, with a significance (two-tailed) p-value = 0.008<0.05. The explanatory power of the combined three modalities of learning on English listening performance was 15.4%, and classroom learning had the highest level of significance in terms of its explanatory power on listening comprehension, and the test of regression coefficients reached the level of significance (t=3.862, p= 0.002<0.05).