This paper firstly constructs a coupled evaluation index system based on three primary indicators, seven secondary indicators and 29 tertiary indicators for agriculture, culture and tourism. Then the entropy weight-TOPSIS method and the coupling coordination degree model are selected to measure the development of agriculture, culture and tourism industry and the coupling level in Yijun County respectively. Finally, 23 spatially related villages in Yijun county area are selected to reveal the reasons for their spatial differences with spatial measurement model, and analyze the factors affecting the coupled and coordinated development of agricultural, cultural and tourism industries in Yijun county area. From the comprehensive evaluation results, the trend of the development level of agriculture, culture and tourism in 2017-2023 was generally upward, in which the agriculture industry had the highest growth between 2022 and 2023, with an increase of 0.0445. After analyzing the factors influencing the development of the coupled agriculture, culture and tourism industries in the Yijun county region by applying the spatial Durbin model, it was found that the general budget expenditures, human capital, infrastructure construction, fixed asset investment and education investment in the region at a significant level of 0.01 correlation of 0.211, 0.03, 0.082 and 0.085, and education investment in the region at a significant level of 0.1 correlation of 0.211. These five factors significantly affect the Yijun County region agriculture, culture and tourism industry, and deepen the development of integration of tourism industry.