This study focuses on the Dingjiafen slope in Chuxiong City, China, with the aim of improving the accuracy of slope landslide risk prediction. Formulas for calculating the critical soil layer thickness at the onset of slope instability are derived based on the physical model of the slope. Using the Digital Elevation Model (DEM) and ArcGIS, the critical and maximum soil layer thickness of each slope unit are calculated to predict potential landslide areas. FLAC-3D is employed to simulate and analyze the slope’s stability under natural conditions, and the numerical simulation results are compared with the predictions in ArcGIS. The findings reveal variations in the critical and maximum soil layer thickness among different slope units due to diverse topography. The slope units on both sides of the Chumeng Highway slopes, with a critical soil layer thickness ( ) between 1 and 3 meters, are connected, aligning with the results of FLAC-3D three-dimensional numerical simulation and the actual sliding positions on-site. Applying this method to simulate the soil layer thickness at the critical state for each slope unit enables slope stability prediction, offering a new perspective for the analysis and prediction of slope stability.