In this paper, for the influence of non-metallic inclusions on the contact fatigue performance of steel, based on the finite element method and rolling contact fatigue theory, the contact fatigue model of U26Mn2Si2CrNiMo bainitic austenitic steel containing non-metallic inclusions is established. The characteristics of non-metallic inclusions and U26Mn2Si2CrNiMo bainitic austenitic steel are analyzed. To investigate the changes in the composition, density and size of each inclusions during the production steps of U26Mn2Si2CrNiMo bainitic austenitic steel by using the inclusions detection technique in steel, the stress and strain response algorithm and the thermodynamic calculations (deoxidization equilibrium calculations of the steel liquid). To analyze the range of fatigue damage concentration caused by non-metallic inclusions by characterizing the distribution of subsurface fatigue damage in the RCF process of U26Mn2Si2CrNiMo bainitic austenitic steel. Explore the effect of the distribution depth of individual non-metallic inclusions on the contact fatigue life of U26Mn2Si2CrNiMo bainitic austenitic steel, and the role of the angle of arrangement of dual nonmetallic inclusions on the properties of U26Mn2Si2CrNiMo bainitic austenitic steel. When circular alumina inclusions with a radius of 5 m are located at different depths of the bainitic austenitic steel, the von Mises stress reaches a maximum value of 770.0 MPa at a depth of 0.53 mm (0.67 Hb ) of inclusions, which is increased by 18.5% compared to the case without inclusions (650 MPa). When the spacing of the two inclusions is 2.5 r (12.5 m ) and the depth is 0.5 mm, the arrangement of the nonmetallic inclusions affects the predicted fatigue life, and the two inclusions reduce the predicted fatigue life around them to different degrees.