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The promotion of industrial digital transformation is an important breakthrough in the change of economic structure and physical space layout, which can promote the entire industrial chain to the high-end value chain and win more profit space and voice for the integration of domestic and international industries into the international cycle. This study takes the cities in the Yangtze River Delta Economic Belt as an example to deeply explore the spatial effect of digital transformation on the healthy transformation of traditional industrial structure, and constructs relevant spatial coupling models to carry out empirical verification by taking the opportunity of putting forward relevant assumptions. The experimental results show that the model is significant at a significance level of more than 5%, which is suitable for the selection of spatial measurement model. The mean square error of its network simulation output is 0.1333, which verifies the expected hypothesis and proves that the digital transformation of the model has a significant spatial driving effect on industrial upgrading.