The hyper-star graph is defined as follows: its vertex-set is the set of -sequences of length with weight , where the weight of a sequence is the number of s in , and two vertices are adjacent if and only if one can be obtained from the other by exchanging the first symbol with a different symbol ( with , or with ) in another position. In this paper, we will find the automorphism groups of regular hyper-star and folded hyper-star graphs. Then, we will show that only the graphs and are Cayley graphs.