The promotion of industrial digital transformation is a crucial breakthrough in the evolution of economic structures and the physical layout of spaces. It has the potential to elevate the entire industrial chain to a high-end value chain, creating more profit opportunities and enhancing the influence of domestic industries in the international cycle. This study uses the cities in the Yangtze River Delta Economic Belt as a case study to explore the spatial effects of digital transformation on the healthy transformation of traditional industrial structures. It constructs relevant spatial coupling models and empirically verifies them by testing specific assumptions. The experimental results indicate that the model is significant at a level greater than 5%, making it suitable for selecting spatial measurement models. The mean square error of its network simulation output is 0.1333, confirming the expected hypothesis and demonstrating that digital transformation has a significant spatial driving effect on industrial upgrading.