This paper synthesizes relevant theoretical knowledge and construction principles, selects 20 evaluation indicators to constitute the evaluation system, and divides the evaluation system into two subsystems in order to more intuitively demonstrate the relationship between international trade network optimization and regional economic synergy. Setting the source of research data, due to the initial data outline is not uniform, the research data for the dimensionless processing. Then the weight values of each index are calculated with the help of entropy weight method, and their values are substituted into the coupled synergy model of the fusion evolutionary algorithm. It is calculated that the synergy level of international trade network optimization and regional economy is medium in the period of 2014~2016, the coordination level of the two has been significantly improved in the period of 2017~2021, and the coordination level is good, and the coordination level of international trade network optimization and regional economy rises to excellent in the period of 2022~2023.