Giving full play to the vitality and autonomy of inter-governmental departments can improve the national governance system and enhance the modernized governance capacity. This paper conducts a relevant research on the coordination mechanism between multiple government departments. According to the network analysis method, the relationships of departments in different service items and fields are studied, and the causes of the problems of power distribution and coordination mechanism in the network of departmental relationships are explained, and the analysis of the influence mechanism of departmental coordination is completed by using the random forest algorithm. The analysis results show that the power of government departments in the fields of housing security, social insurance, labor, employment and entrepreneurship, public education, and health care is more concentrated, and the Ministry of Civil Affairs and the Ministry of Human Resources and Social Security have an active position in the coordination process. Cultural cognitive bias, imbalance of power and responsibility, lack of coordination system guarantee and insufficient support of coordination environment are the causes of problems in the coordination mechanism. In addition, ambiguous coordination responsibilities, imperfect institutionalized coordination and lack of supervision system are important factors affecting the multisectoral coordination mechanism.