The development of Artificial Intelligence has renewed the direction of art history, making the relationship between technology and art a matter of great interest once again. The application of artificial intelligence in the field of fashion design brings new tools to the designers’ way of designing and displaying. This paper researches artificial intelligence technology and analyzes the application of artificial intelligence as an auxiliary means in the field of art and design, and deeply researches the way of applying artificial intelligence in fashion design as well as its advantages. It also researches the intelligent image generation problem under the fashion big data environment, adopts the method of fusing the external features of fashion images and decoupling the internal features, and provides theoretical methods and bases for the controllable generation of fashion images based on the architecture of generative adversarial network. A multiconditional information fusion generative adversarial network architecture (MCF-GAN) is proposed, and the experimental results show that the image generation performance of the model in this paper is excellent, and better performance is obtained compared with other comparative methods. And it is applied to the actual fashion design for evaluation, the designer’s evaluation in all dimensions are more than 10 points, indicating that the method in this paper has a better application value in fashion design, and provides an effective path for fashion design optimization.