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In order to study the role of digital economy on the transformation of regional economic structure, firstly, the mechanism of the role of datatized economy on the change of regional economic form is elaborated, and on the basis of the analysis of theoretical model, the structure of the distribution of capital factors in each industry and the ideal factor are determined. Determine the index system and weights of regional economic structure transformation through the selection of weight indicators, and complete the measurement of the data-based economic situation under the construction of the index system of data-based economic situation. Two hypotheses are proposed that digital industrialization can have an ideal effect on the structural transformation of local development but the shape of the effect is inverted U-shape, and that industrial digitalization can have an ideal effect on the structural transformation of local development. The empirical analysis finds that the Moran’s I index of structural transformation of local development from 2008 to 2020 is prominent in the 1% case, and the FP and UE within, central, eastern, western regions of China and the level of structural transformation of local economy is prominent in the 1% case. It is concluded that there is a prominent spatial isotropic relationship between the datadriven economy on regional economic structural change resilience in the whole region, and the constructed research model has a good robustness.