In this paper, we introduce a generalized family of numbers and polynomials of one or more variables attached to the formal composition of generating functions , , and . We give explicit formulae and apply the obtained result to two special families of polynomials; the first concerns the generalization of some polynomials applied to the theory of hyperbolic differential equations recently introduced and studied by and . The second concerns two-variable Laguerre-based generalized Hermite-Euler polynomials introduced and should be updated to studied recently by .