Let be integers. Define to be the <i>transportation polytope</i> consisting of the non-negative real matrices whose rows each sum to and whose columns each sum to . The special case is the much-studied <i>Birkhoff-von Neumann polytope</i> of doubly-stochastic matrices. Using a recent asymptotic enumeration of non-negative integer matrices (Canfield and McKay, 2007), we determine the asymptotic volume of as with such that neither decreases nor increases too quickly. In particular, we give an asymptotic formula for the volume of .