We show that every generalized quadrangle of order \((4,6)\) with a spread of symmetry is isomorphic to the Ahrens-Szekeres generalized quadrangle \(\text{AS}(5)\). It then easily follows that every generalized quadrangle of order \(5\) with an axis of symmetry is isomorphic to the classical generalized quadrangle \(\text{Q}(4, 5)\).