A -design on points is a set of subsets (blocks) of a -set such that any two distinct blocks meet in exactly points and not all of the blocks have the same size. Ryser’s and Woodall’s -design conjecture states that all -designs can be obtained from symmetric designs by a complementation procedure. In this paper, we establish feasibility criteria for the existence of -designs with two block sizes in the form of integrality conditions, equations, inequalities, and Diophantine equations involving various parameters of the designs. We use these criteria and a computer to prove that the -design conjecture is true for all -designs with two block sizes with and .