A set of vertices in a graph is a total dominating set if every vertex of has at least one neighbor in . The minimum cardinality of a total dominating set of is called the total domination number of , denoted by . A total dominating set of with cardinality is called a -set of . We characterize trees with unique -sets. Further, we prove that for graphs with unique -sets, and we characterize all graphs with unique -sets where .