Let be a finite simple connected graph. For any vertex in , let be the open neighbourhood of , and let be the closed neighbourhood of . A connected graph is said to be neighbourhood highly irregular (or simply NHI) if for any vertex , any two distinct vertices in the open neighbourhood of have distinct closed neighbourhood sets. In this paper, we give a necessary and sufficient condition for a graph to be NHI. For any , we obtain a lower bound for the order of regular NHI graphs and a sharp lower bound for the order of NHI graphs with clique number , which is better than the bound attained earlier.