Let be the symmetric inverse semigroup on a finite nonempty set , and let be a subset of . Let be the graph obtained by deleting vertex from the Cayley graph . We obtain conditions on for it to be -vertex-transitive and -vertex-transitive. The basic structure of vertex-transitive is characterized. We also investigate the undirected Cayley graphs of symmetric inverse semigroups, and prove that the generalized Petersen graph can be constructed as a connected component of a Cayley graph of a symmetric inverse semigroup, by choosing an appropriate connecting set.