In this paper, we give sufficient conditions for the existence of kernels by monochromatic directed paths (m.d.p.) in digraphs with quasi-transitive colorings. Let be an -colored digraph. We prove that if every chromatic class of is quasi-transitive, every cycle is quasi-transitive in the rim and does not contain polychromatic triangles, then has a kernel by m.d.p. The same result is valid if we preserve the first two conditions before and replace the last one by: there exists such that every is quasi-monochromatic and every () is not polychromatic. Finally, we also show that if every chromatic class of is quasi-transitive, every cycle in induces a quasi-transitive digraph and does not contain polychromatic , then has a kernel by m.d.p. Some corollaries are obtained for the existence of kernels by m.d.p. in -colored tournaments.