Let An be the alternating group of degree n with n≥5. Set S={(1ij),(1ji)∣2≤i,j≤n,i≠j}. In this paper, it is shown that the full automorphism group of the Cayley graph Cay(An,S) is the semi-product R(An)⋊Aut(An,S), where R(An) is the right regular representation of An and Aut(An,S)={ϕ∈Aut(An)∣Sϕ=S}≅Sn−1.