For a graph , the modified Schultz index of is defined as , where (or )is the degree of the vertex in , and is the distance between and . The first Zagreb index is equal to the sum of the squares of the degrees of the vertices, and the second Zagreb index is equal to the sum of the products of the degrees of pairs of adjacent vertices. In this paper, we present a unified approach to investigate the modified Schultz index and Zagreb indices of tricyclic graphs. The tricyclic graph with vertices having minimum modified Schultz index and maximum Zagreb indices are determined.