The structure and the hamiltonicity of vertex-transitive graphs of order , where and are distinct primes, are studied. It is proved that if and and is a vertex-transitive graph of order such that contains an imprimitive subgroup, then either is a circulant or partitions into subsets of cardinality such that there exists a perfect matching between any two of them. Partial results are obtained for . Moreover, it is proved that every connected vertex-transitive graph of order is hamiltonian.