A dominating set is a vertex subset of a graph such that each vertex of is either in or adjacent to a vertex in . The domination number, , is the minimum cardinality of a dominating set of a graph . In this paper, we will investigate the domination number of Fibonacci cubes. We firstly study the degree sequence of the Fibonacci cubes. Then, a lower bound for the domination number of Fibonacci cube of order is obtained, and the exact value of the domination number of Fibonacci cubes of order at most is determined.