The n-dimensional enhanced hypercube is one of the most attractive interconnection networks for parallel and distributed computing system. Let be a certain particular connected subgraph of graph . The -structure-connectivity of , denoted by is the cardinality of minimal set of subgraphs in such that every is isomprphic to and is disconnected. The -substructure-connectivity of , denoted by , is the cardinality of minimal set of subgraphs in such that every is isomorphic to a connected subgraph , and is disconnected. Using the structural properties of the -structure-connectivity were determine for .